Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GANAB | Q14697 | 3/20 | 0.60 |
| ▸ | GBA1 | P04062 | 1/20 | 0.60 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | AGL | P35573 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.38 |
| ▸ | MAN2B2 | Q9Y2E5 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL3430488 | 0.89 | GANAB (0.50) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL7032907 | 0.81 | GBA1 (0.62) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL8170879 | 0.81 | GBA1 (0.88) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL8171453 | 0.81 | GBA1 (0.88) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL19328384 | 0.81 | GBA1 (0.62) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL23531404 | 0.81 | GBA1 (0.62) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL8170898 | 0.81 | GBA1 (0.88) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL9495785 | 0.81 | GBA1 (0.62) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL2265142 | 0.81 | GBA1 (0.62) | GANABGBA1GLB1MGAMGAA | |
| SCHEMBL8171977 | 0.81 | GBA1 (0.88) | GANABGBA1GLB1MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292256-B1 | High mannose proteins and methods of making high mannose proteins | SHIRE HUMAN GENETIC THERAPIES (US) | 2018-08-01 | — | — | EP | claimed |
| EP-0424350-B1 | Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol | MONSANTO CO (US) | 1995-02-01 | — | — | EP | claimed |
| EP-0424350-A1 | Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol | MONSANTO COMPANY (US) | 1991-04-24 | — | — | EP | claimed |
| US-4996329-A | Enzyme inhibitors, viricides | MONSANTO COMPANY (US) | 1991-02-26 | — | — | US | claimed |
| EP-4681775-A2 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | Icahn School of Medicine at Mount Sinai (US) | 2026-01-21 | — | — | EP | disclosed |
| EP-3998078-B1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL MED MOUNT SINAI (US) | 2025-10-01 | — | — | EP | disclosed |
| US-20220305091-A1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-09-29 | — | — | US | disclosed |
| EP-3998078-A1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | Icahn School of Medicine at Mount Sinai (US) | 2022-05-18 | — | — | EP | disclosed |
| EP-3482767-B1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL MED MOUNT SINAI (US) | 2021-10-06 | — | — | EP | disclosed |
| US-20210077593-A1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-03-18 | — | — | US | disclosed |
| US-20190151419-A1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-05-23 | — | — | US | disclosed |
| EP-2470199-B1 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-05-22 | — | — | EP | disclosed |
| US-7138262-B1 | Preparation of high mannose glucocerebrosidase having at least four mannose residues by contacting a cell that expresses a human glucocerebrosidase with kifunensine and harvesting | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-5773239-A | ENZYME INHIBITORS FORMED BY MULTISTAGE REACTION FOR USE AS PRODRUGS | MOUNT SINAI HOSPITAL CORPORATION. (CA) | 1998-06-30 | — | — | US | disclosed |
| EP-0424350-B1 | Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol | MONSANTO CO (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5041555-A | Mannosidase inhibitors | MONSANTO COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5041555-A | Mannosidase inhibitors | MONSANTO COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0424350-A1 | Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol | MONSANTO COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4996329-A | Enzyme inhibitors, viricides | MONSANTO COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| US-4996329-A | Enzyme inhibitors, viricides | MONSANTO COMPANY (US) | 1991-02-26 | — | — | US | disclosed |