Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308103 | 0.99 | PTGS1 (0.36) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| SCHEMBL5307952 | 0.98 | PTGS1 (0.36) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| Hydrochloric Acid SCHEMBL5310493 | 0.98 | PTGS1 (0.36) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| Hydrochloric Acid SCHEMBL5311251 | 0.98 | PTGS1 (0.35) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| SCHEMBL5308091 | 0.98 | PTGS1 (0.37) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| Maleic Acid SCHEMBL5310425 | 0.95 | PTGS1 (0.34) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| Fumaric Acid SCHEMBL5308083 | 0.95 | PTGS1 (0.34) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| Fumaric Acid SCHEMBL5308085 | 0.95 | PTGS1 (0.34) | PTGS1PTGS2PTGDR2P2RX4HTR2A | |
| SCHEMBL5309990 | 0.92 | PTGS1 (0.34) | PTGS1PTGS2PTGDR2HTR2AHTR2C | |
| SCHEMBL5308109 | 0.90 | PTGS1 (0.37) | PTGS1PTGS2PTGDR2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099986-A1 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099986-A1 | Preventives/remedies for urinary disturbance | REN, GLS, ATP6V1B1 | HTR1A 909/4885SLC6A4 1666/4885PTGS1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.