SCHEMBL5577029

SCHEMBL5577029

O=C(O)c1cc(C(F)(F)F)ccc1NC(=O)C1CC1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LIPC P11150 1/20 0.61
LIPG Q9Y5X9 1/20 0.61
KMT2A Q03164 2/20 0.59
MEN1 O00255 1/20 0.59
TSHR P16473 1/20 0.59
RXFP1 Q9HBX9 7/20 0.57
KDM4E B2RXH2 2/20 0.51
KDM1A O60341 2/20 0.50
HSD17B10 Q99714 1/20 0.50
PLK1 P53350 1/20 0.48
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
CCR2 P41597 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5114074 0.93 KMT2A (0.62) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL6105872 0.83 RXFP1 (0.55) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1826584 0.83 MEN1 (0.46) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1826585 0.83 MEN1 (0.46) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL4603837 0.82 KDM4E (0.54) RXFP1KDM4EHSD17B10
SCHEMBL1827461 0.82 KMT2A (0.50) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1827641 0.82 KDM4E (0.51) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1821782 0.82 RXRA (0.59) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1827463 0.82 KMT2A (0.50) LIPCLIPGKMT2AMEN1TSHR
SCHEMBL1826814 0.81 MRGPRX4 (0.56) LIPCLIPGKMT2AMEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070066586-A1 ANILINE DERIVATIVES AJINOMOTO CO., INC. (JP) 2007-03-22 US disclosed
EP-1736465-A1 ANILINE DERIVATIVES Ajinomoto Co., Inc. (JP) 2006-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066586-A1 ANILINE DERIVATIVES SERPINB1, ACE, REN LIPC 2200/4885LIPG 720/4885KMT2A 519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.