SCHEMBL5577035

SCHEMBL5577035

N#Cc1ccc(-n2c(=O)c3c(C(F)(F)F)c4c(=O)n(-c5ccc(C#N)c(C#N)c5)c(=O)c4c(C(F)(F)F)c3c2=O)cc1C#N

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
AR P10275 12/20 0.41
BCAT2 O15382 1/20 0.37
BCAT1 P54687 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5576255 0.90 AR (0.53) AR
SCHEMBL5575206 0.86 AR (0.50) AR
SCHEMBL5576820 0.82 AR (0.49) AR
SCHEMBL5576251 0.81 KIF11 (0.41)
SCHEMBL5573815 0.79 MIF (0.37) AR
SCHEMBL5575559 0.78 LMNA (0.49) ALDH1A1LMNAHPGDMAPK1SMN1; SMN2
SCHEMBL5535430 0.76 KDM4E (0.49) ALDH1A1LMNAHPGDMAPK1SMN1; SMN2
SCHEMBL5535450 0.73 GSK3A (0.47)
SCHEMBL5535884 0.71 KAT2B (0.40)
SCHEMBL5531653 0.71 CYP1A2 (0.51) ALDH1A1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8168327-B2 Imide derivative, material for organic electroluminescent device and organic electroluminescent device using the same IDEMITSU KOSAN CO., LTD. (JP) 2012-05-01 US disclosed
US-20070160905-A1 NOVEL IMIDE DERIVATIVE, MATERIAL FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-07-12 US disclosed