Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69699 | 0.83 | NR4A1 (0.54) | NAPRTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1893432 | 0.78 | KDM4E (0.65) | NAPRTPARP1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11797746 | 0.78 | TTR (0.51) | ALDH1A1LMNAHPGDCYSLTR1GPR35 | |
| SCHEMBL10949915 | 0.76 | NR4A1 (0.47) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL783749 | 0.71 | NR4A1 (0.50) | KDM4EALDH1A1CYSLTR1GPR35NR4A1 | |
| SCHEMBL40257 | 0.71 | NAPRT (0.52) | NAPRTPARP1KDM4EALDH1A1KEAP1 | |
| SCHEMBL29684913 | 0.71 | NAPRT (0.52) | NAPRTPARP1KDM4EALDH1A1KEAP1 | |
| SCHEMBL7829853 | 0.70 | PTPN1 (0.46) | ALDH1A1LMNAHPGDCYSLTR1GPR35 | |
| SCHEMBL23611795 | 0.70 | PARP1 (0.50) | NAPRTPARP1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5577114 | 0.70 | TTR (0.49) | PARP1KDM4EHSD17B10ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | claimed |
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | disclosed |
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | PDE7A, PDE10A, PDE2A | NAPRT 1840/4885PARP1 3933/4885KDM4E 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.