Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930499 | 0.78 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL4931103 | 0.77 | MEN1 (0.50) | ALDH1A1MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL5577214 | 0.75 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL12752842 | 0.69 | ADRB1 (0.53) | ALDH1A1LMNAHTTAKR1C3 | |
| SCHEMBL24309509 | 0.68 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1MAPTTSHRHPGD | |
| SCHEMBL1491177 | 0.68 | GAA (0.54) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16432438 | 0.68 | IGF1R (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11299409 | 0.68 | MAPT (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL24421699 | 0.68 | ESR1 (0.43) | ALDH1A1MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL11296569 | 0.68 | MAPT (0.66) | ALDH1A1MEN1KMT2ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |