⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006501 | 1.00 | — | — | |
| SCHEMBL5031088 | 0.80 | CA1 (0.35) | — | |
| SCHEMBL26676513 | 0.79 | — | — | |
| SCHEMBL15803229 | 0.79 | — | — | |
| SCHEMBL5027508 | 0.78 | ACHE (0.31) | — | |
| SCHEMBL5032364 | 0.78 | ACHE (0.31) | — | |
| SCHEMBL5029872 | 0.78 | ACHE (0.31) | — | |
| SCHEMBL301584 | 0.78 | CA1 (0.33) | — | |
| SCHEMBL16569783 | 0.78 | CA1 (0.33) | — | |
| SCHEMBL3468216 | 0.77 | SMN1; SMN2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179100-A1 | Protected monomers | ALNYLAM PHARMACEUTICALS, INC. | 2007-08-02 | — | — | US | disclosed |
| EP-1625138-A2 | PROTECTED MONOMERS | Alnylam Pharmaceuticals Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| US-20040242530-A1 | Orthoester protecting groups | DHARMACON, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004094345-A2 | PROTECTED MONOMERS | ALNYLAM PHARMACEUTICALS INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| US-6590093-B1 | Modified RNA which can be easily handled and analyzed with minimal degradation; stability; can use in synthesis of polymers containing RNA nucleotides | DHARMACON, INC. | 2003-07-08 | — | — | US | disclosed |
| US-6111086-A | BLOCKING AGENTS FOR 2'-O POSITION DURING RNA SYNTHESIS; CLEAVABLE UNDER MILD ACIDIC CONDITIONS LEAVING QUALITY RNA | DHARMACON, INC. | 2000-08-29 | — | — | US | disclosed |