Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577980 | 0.86 | CSNK2A2 (0.49) | RAB9ASMN1; SMN2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL14454811 | 0.81 | RAB9A (0.50) | RAB9ASMN1; SMN2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL18576414 | 0.74 | GSK3A (0.43) | RAB9ASMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL14531004 | 0.70 | SENP2 (0.49) | RAB9ASMN1; SMN2MAPTNPC1TSHR | |
| SCHEMBL14454837 | 0.70 | MAOB (0.54) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL14336397 | 0.68 | GAA (0.64) | RAB9ASMN1; SMN2ALDH1A1ALPLNPC1 | |
| SCHEMBL822367 | 0.68 | NPC1 (0.75) | RAB9ASMN1; SMN2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL3579484 | 0.67 | MAPT (0.84) | RAB9ASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL6933552 | 0.67 | ALPL (0.52) | RAB9ASMN1; SMN2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL2916913 | 0.67 | CCNA2 (0.72) | RAB9ASMN1; SMN2ADORA3ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | MAP4K2, MAP4K5, MAP4K3 | RAB9A 1840/4885SMN1; SMN2 3826/4885ADORA3 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.