Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346586 | 0.89 | L3MBTL1 (0.41) | MAPTDPP4L3MBTL1HTR2AHTR2C | |
| SCHEMBL557875 | 0.81 | CASP1 (0.62) | SLC6A3SLC6A4SLC6A2CASP1GAA | |
| SCHEMBL558523 | 0.80 | CASP1 (0.61) | SLC6A3SLC6A4SLC6A2CASP1GAA | |
| Hydrochloric Acid SCHEMBL9427976 | 0.77 | CASP1 (0.61) | SLC6A3SLC6A4SLC6A2CASP1GAA | |
| SCHEMBL9719037 | 0.76 | MAPT (0.54) | MAPTL3MBTL1PTGS2 | |
| SCHEMBL31062122 | 0.74 | CASP1 (0.54) | SLC6A3SLC6A4SLC6A2CASP1GAA | |
| SCHEMBL26921463 | 0.73 | SLC6A4 (0.58) | SLC6A3SLC6A4SLC6A2CASP1GAA | |
| SCHEMBL3351972 | 0.72 | CASP1 (0.55) | MAPTL3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL29023628 | 0.72 | DPP4 (0.53) | DPP4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7896714 | 0.71 | SLC6A4 (0.61) | DPP4SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-02-09 | — | — | US | disclosed |
| CN-1886393-A | Modulators of ATP-binding cassette transporters containing cycloalkyl or pyranyl groups | VERTEX PHARMA (US) | 2006-12-27 | — | — | CN | disclosed |
| EP-1680411-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS | Vertex Pharmaceuticals Incorporated (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005035514-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | MAPT 2703/4885DPP4 2478/4885L3MBTL1 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.