Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578656 | 0.87 | TNKS (0.44) | TACR1GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL16162422 | 0.85 | USP30 (0.43) | TACR1MAPTGPR119SYKSTS | |
| SCHEMBL16162442 | 0.85 | USP30 (0.43) | TACR1MAPTGPR119SYKSTS | |
| SCHEMBL16086562 | 0.85 | USP30 (0.43) | TACR1MAPTGPR119SYKSTS | |
| SCHEMBL1195130 | 0.84 | AVPR1A (0.47) | STSHDAC1HDAC8HDAC6MAPK1 | |
| SCHEMBL1195132 | 0.84 | AVPR1A (0.47) | STSHDAC1HDAC8HDAC6MAPK1 | |
| SCHEMBL5578756 | 0.84 | ALDH1A1 (0.46) | MAPTGPR119STSHDAC1HDAC8 | |
| SCHEMBL12877996 | 0.82 | MAPK1 (0.38) | TACR1MAPTGPR119HDAC1HDAC8 | |
| SCHEMBL1195962 | 0.82 | GPR119 (0.44) | GPR119MAPK1USP30JAK2JAK1 | |
| SCHEMBL1195964 | 0.82 | GPR119 (0.44) | GPR119MAPK1USP30JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087072-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | Zoetis Services LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20160296499-A1 | Spiroindoline Antiparasitic Derivatives | ZOETIS SERVICES LLC | 2016-10-13 | — | — | US | disclosed |
| WO-2015100232-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | ZOETIS SERVICES LLC (US) | 2015-07-02 | — | — | WO | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | REN, AVPR2, RECQL | TACR1 224/4885MAPT 2939/4885GPR119 517/4885 |
| US-20160296499-A1 | Spiroindoline Antiparasitic Derivatives | PKD2, PKD1, AVPR2 | TACR1 26/4885MAPT 4482/4885GPR119 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.