Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.49 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.38 |
| ▸ | NOS1 | P29475 | 6/20 | 0.35 |
| ▸ | NOS2 | P35228 | 5/20 | 0.35 |
| ▸ | NOS3 | P29474 | 4/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 3/20 | 0.33 |
| ▸ | ARG2 | P78540 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL1278143 | 1.00 | GSR (0.49) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL21816544 | 0.92 | GSR (0.57) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL2482348 | 0.91 | GSR (0.47) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL11660913 | 0.90 | GNAI3 (0.46) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL301607 | 0.90 | GNAI3 (0.46) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28634978 | 0.89 | GSR (0.53) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL2057401 | 0.88 | GNAI3 (0.44) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL6535302 | 0.88 | GSR (0.45) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL8957537 | 0.87 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL3516723 | 0.87 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070094750-A1 | Novel ADC polynucleotides and polypeptides, uses thereof including methods for improving seeds | CERES, INC. (US) | 2007-04-26 | — | — | US | disclosed |
| US-7126043-B1 | ADC polynucleotides and polypeptides, uses thereof including methods for improving seeds | CERES, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1155123-A4 | NOVEL ADC POLYNUCLEOTIDES AND POLYPEPTIDES, USES THEREOF INCLUDING METHODS FOR IMPROVING SEEDS | CERES INC (US) | 2005-12-21 | — | — | EP | disclosed |
| EP-1155123-A1 | NOVEL ADC POLYNUCLEOTIDES AND POLYPEPTIDES, USES THEREOF INCLUDING METHODS FOR IMPROVING SEEDS | Ceres, Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050585-A1 | NOVEL ADC POLYNUCLEOTIDES AND POLYPEPTIDES, USES THEREOF INCLUDING METHODS FOR IMPROVING SEEDS | CERES, INC. (US) | 2000-08-31 | — | — | WO | disclosed |