Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.45 |
| ▸ | FDPS | P14324 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL28250413 | 0.98 | TP53 (0.68) | TP53ACE2GPR84FDPSCA1 | |
| Sulfuric Acid SCHEMBL28183823 | 0.90 | TP53 (0.55) | TP53ACE2GPR84FDPSCA1 | |
| SCHEMBL671913 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| SCHEMBL3002559 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| SCHEMBL5306193 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| Hexadecane SCHEMBL23000686 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| Octane SCHEMBL7455770 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| SCHEMBL6122664 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| SCHEMBL22950680 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA | |
| SCHEMBL344997 | 0.84 | OPRM1 (0.55) | ACE2GPR84FDPSSPHK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105115-A1 | Promoter of the human fatp5 gene and uses | MERCK SANTE (FR) | 2007-05-10 | — | — | US | disclosed |
| EP-1658310-A1 | PROMOTER OF THE HUMAN FATP5 GENE AND USES | MERCK PATENT GmbH (DE) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005021590-A1 | PROMOTER OF THE HUMAN FATP5 GENE AND USES | MERCK PATENT GMBH (DE) | 2005-03-10 | — | — | WO | disclosed |