Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.32 |
| ▸ | CTSB | P07858 | 8/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128057 | 0.84 | FLT3 (0.39) | — | |
| SCHEMBL5579540 | 0.77 | BACE1 (0.33) | BACE1CTSBCTSD | |
| SCHEMBL5579788 | 0.73 | HTT (0.34) | BACE1CTSB | |
| SCHEMBL5118902 | 0.71 | BACE1 (0.30) | BACE1CTSBCTSD | |
| SCHEMBL5579870 | 0.69 | HTR7 (0.31) | BACE1CTSD | |
| SCHEMBL5579814 | 0.68 | BACE1 (0.33) | BACE1CTSBCTSD | |
| SCHEMBL5579770 | 0.64 | BACE1 (0.32) | BACE1CTSBCTSD | |
| SCHEMBL5389512 | 0.54 | BACE1 (0.54) | BACE1CTSBCTSD | |
| SCHEMBL3351689 | 0.53 | BACE1 (0.67) | BACE1CTSBCTSD | |
| SCHEMBL3351683 | 0.53 | BACE1 (0.67) | BACE1CTSBCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |