Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.32 |
| ▸ | CTSB | P07858 | 8/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | YES1 | P07947 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579814 | 0.72 | BACE1 (0.33) | BACE1CTSBCTSD | |
| SCHEMBL5579870 | 0.66 | HTR7 (0.31) | BACE1CTSD | |
| SCHEMBL5118902 | 0.66 | BACE1 (0.30) | BACE1CTSBCTSD | |
| SCHEMBL5579788 | 0.65 | HTT (0.34) | BACE1CTSBHSD17B10KMT2A | |
| SCHEMBL5579545 | 0.64 | BACE1 (0.32) | BACE1CTSBCTSD | |
| SCHEMBL5579589 | 0.64 | IMPDH2 (0.38) | — | |
| SCHEMBL5579540 | 0.64 | BACE1 (0.33) | BACE1CTSBCTSD | |
| SCHEMBL5579768 | 0.62 | BACE1 (0.40) | BACE1CTSBCTSDKMT2A | |
| SCHEMBL5579799 | 0.62 | BACE1 (0.40) | BACE1CTSBCTSDKMT2A | |
| SCHEMBL5579783 | 0.62 | BACE1 (0.40) | BACE1CTSBCTSDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |