SCHEMBL557980

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2554374	0.86	TSHR (0.39)	LMNAMAPK1NLRP1HTTMEN1
	SCHEMBL2548882	0.83	DDR1 (0.38)	LMNAMAPK1NLRP1CYP1A2CYP2D6
	SCHEMBL22776522	0.82	ALDH1A1 (0.52)	HTTMEN1KMT2AALDH1A1NPC1
	SCHEMBL29978873	0.82	ALDH1A1 (0.52)	HTTMEN1KMT2AALDH1A1NPC1
	SCHEMBL2552891	0.78	HTR2A (0.38)	LMNAHTTMEN1KMT2ACYP1A2
	SCHEMBL559497	0.77	APEX1 (0.44)	LMNAMAPTALOX12NPC1RAB9A
	SCHEMBL15928198	0.77	LMNA (0.52)	LMNAMAPK1NLRP1HTTMEN1
	SCHEMBL2555265	0.76	KDM1A (0.31)	MEN1KMT2ATSHR
	SCHEMBL558635	0.75	TSHR (0.57)	LMNAMAPK1MEN1KMT2AALDH1A1
	SCHEMBL557943	0.75	P2RX7 (0.43)	MEN1KMT2AALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.