Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.39 |
| ▸ | CPB1 | P15086 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28560079 | 1.00 | GSR (0.48) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL4297918 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL4294462 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| D-Histidine SCHEMBL902054 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL305856 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL305855 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL18419548 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL16714200 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL27767215 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL27440707 | 0.94 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | claimed |
| EP-3103446-B1 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | ZAKHAROV IVAN DMITRIEVICH (RU) | 2024-02-14 | — | — | EP | disclosed |
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | disclosed |
| US-20070098702-A1 | Recombinant protein polymer vectors for systemic gene delivery | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |