Pemoline

Pemoline

SCHEMBL558128

N=C1NC(=O)C(c2ccccc2)O1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.67
KDM4E B2RXH2 4/20 0.43
POLB P06746 2/20 0.43
MAPT P10636 1/20 0.43
ALDH1A1 P00352 6/20 0.43
RAB9A P51151 1/20 0.41
SLC6A3 Q01959 1/20 0.41
BRD4 O60885 1/20 0.39
CREBBP Q92793 1/20 0.39
GSK3B P49841 1/20 0.39
KMT2A Q03164 3/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
DDB1 Q16531 1/20 0.37
CRBN Q96SW2 1/20 0.37
LMNA P02545 1/20 0.37
MAPK1 P28482 1/20 0.37
HPGD P15428 2/20 0.35
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pemoline Dione SCHEMBL7864463 0.80 CA2 (1.00) CA2KDM4EPOLBMAPTALDH1A1
Pemoline Dione SCHEMBL11265294 0.78 CA2 (0.96) CA2KDM4EPOLBMAPTALDH1A1
SCHEMBL8181404 0.77 CA2 (0.67) CA2KDM4EPOLBMAPTALDH1A1
SCHEMBL5670399 0.74 CA2 (0.62) CA2KDM4EPOLBALDH1A1BRD4
SCHEMBL31650964 0.69 ALDH1A1 (0.56) CA2KDM4EPOLBMAPTALDH1A1
SCHEMBL4969066 0.68 CA2 (0.54) CA2KDM4EPOLBALDH1A1BRD4
SCHEMBL4969956 0.68 CA2 (0.54) CA2KDM4EPOLBMAPTALDH1A1
SCHEMBL21695777 0.68 CA2 (0.54) CA2KDM4EPOLBMAPTALDH1A1
SCHEMBL30991581 0.68 CA2 (0.54) CA2KDM4EPOLBALDH1A1BRD4
SCHEMBL983728 0.68 ALDH1A1 (0.54) CA2KDM4EPOLBMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 301 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
US-20220362160-A1 ABUSE RESISTANT CAPSULE R.P. SCHERER TECHNOLOGIES, LLC (US) 2022-11-17 US claimed
US-11464747-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2022-10-11 US claimed
CN-110585165-B Abuse resistant capsules R·P·谢勒技术有限公司 2022-08-12 CN claimed
EP-3446681-B1 ABUSE RESISTANT CAPSULE SCHERER TECHNOLOGIES LLC R P (US) 2020-12-23 EP claimed
CN-110585165-A Abuse resistant capsules R·P·谢勒技术有限公司 2019-12-20 CN claimed
US-10420729-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2019-09-24 US claimed
EP-2968129-B1 ABUSE RESISTANT CAPSULE SCHERER TECHNOLOGIES LLC R P (US) 2018-09-05 EP claimed
EP-2968129-A1 ABUSE RESISTANT CAPSULE R.P. Scherer Technologies, LLC (US) 2016-01-20 EP claimed
CN-105255570-A Fully-synthetic type metal cutting fluid YANTAI SHUNLONG CHEMICAL TECHNOLOGY CO LTD 2016-01-20 CN claimed
US-20100098758-A1 Abuse-Resistant Dosage Form GRUENENTHAL GMBH (DE) 2010-04-22 US claimed
EP-1515702-B1 ABUSE-PROTECTED ADMINISTRATION FORM GRUENENTHAL GMBH (DE) 2008-10-15 EP claimed
EP-1558221-B1 DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE GRUENENTHAL GMBH (DE) 2007-06-06 EP claimed
US-20050214223-A1 Abuse-safeguarded dosage form GRUENENTHAL GMBH (DE) 2005-09-29 US claimed
US-20050191244-A1 Abuse-resistant pharmaceutical dosage form GRUENENTHAL GMBH (DE) 2005-09-01 US claimed
US-20050186139-A1 Abuse-proofed dosage form GRUENENTHAL GMBH (DE) 2005-08-25 US claimed
EP-0948490-A1 PROCESS FOR THE PREPARATION OF 2-IMINO-5-PHENYL-4-OXAZOLIDINONE AND ITS INTERMEDIATES Abbott Laboratories (US) 1999-10-13 EP claimed
WO-1998022450-A1 PROCESS FOR THE PREPARATION OF 2-IMINO-5-PHENYL-4-OXAZOLIDINONE AND ITS INTERMEDIATES ABBOTT LABORATORIES (US) 1998-05-28 WO claimed
US-5708182-A Method for preparation of 2-imino 4-oxo-5-phenyloxazolidine SKW TROSTBERG AKTIENGESELLSCHAFT (DE) 1998-01-13 US claimed
US-5677463-A Process for the preparation of 2-imino-5-phenyl-4 oxazolidinone and its intermediates ABBOTT LABORATORIES (US) 1997-10-14 US claimed