Pemoline Dione

Pemoline Dione

SCHEMBL7864463

O=C1NC(=O)C(c2ccccc2)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 1.00
ALDH1A1 P00352 5/20 0.46
RAB9A P51151 1/20 0.43
SLC6A3 Q01959 1/20 0.43
PPARG P37231 2/20 0.42
PPARD Q03181 1/20 0.42
PPARA Q07869 1/20 0.42
KDM4E B2RXH2 4/20 0.42
POLB P06746 2/20 0.42
MAPT P10636 1/20 0.42
BRD4 O60885 1/20 0.41
CREBBP Q92793 1/20 0.41
GSK3B P49841 1/20 0.41
KMT2A Q03164 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pemoline Dione SCHEMBL11265294 0.98 CA2 (0.96) CA2ALDH1A1RAB9ASLC6A3PPARG
SCHEMBL11038399 0.81 CA2 (0.66) CA2ALDH1A1PPARGPPARDPPARA
SCHEMBL8181404 0.80 CA2 (0.67) CA2ALDH1A1RAB9ASLC6A3KDM4E
SCHEMBL9094584 0.80 CA2 (0.67) CA2ALDH1A1RAB9AKDM4EPOLB
SCHEMBL11040315 0.80 CA2 (0.67) CA2GSK3BKMT2ASMN1; SMN2TDP1
SCHEMBL898510 0.80 CA2 (0.67) CA2ALDH1A1PPARGPPARDPPARA
SCHEMBL10549629 0.80 CA2 (0.67) CA2ALDH1A1RAB9ASLC6A3KDM4E
Pemoline SCHEMBL558128 0.80 CA2 (0.67) CA2ALDH1A1RAB9ASLC6A3KDM4E
SCHEMBL11043058 0.80 CA2 (0.66) CA2ALDH1A1SLC6A3PPARGPPARD
SCHEMBL9188792 0.79 CA2 (0.65) CA2ALDH1A1RAB9ASLC6A3PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641330-B1 GABA AND L-GLUTAMIC ACID ANALOGS FOR ANTISEIZURE TREATMENT UNIV NORTHWESTERN (US) 2001-10-17 EP claimed
US-4489208-A Process for producing D(-)mandelic acid E.N.I. NAZIONALE IDROCARBURI (IT) 1984-12-18 US claimed
US-4332905-A STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF RACEMIC 5-SUBSTITUTED 2,4-OXAZOLIDINEDIONES E.N.I. ENTE NOZIONALE IDROCARBURI (IT) 1982-06-01 US claimed
EP-0703899-A1 ARYLACETAMIDES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS FUNGICIDES Hoechst Schering AgrEvo GmbH (DE) 1996-04-03 EP disclosed
WO-1994029267-A1 ARYLACETAMIDES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS FUNGICIDES HOECHST SCHERING AGREVO GMBH (DE) 1994-12-22 WO disclosed
EP-0097453-B1 ALICYCLIC SUBSTITUTED OXAZOLIDINE-2,4-DIONES HAVING HYPOGLYCEMIC ACTIVITY PFIZER INC. (US) 1990-04-11 EP disclosed
US-4812471-A Hypoglycemic 5-(isoxazolyl or isothiazolyl)-oxazolidine-2,4-diones PFIZER INC. (US) 1989-03-14 US disclosed
US-4753956-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1988-06-28 US disclosed
US-4695634-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1987-09-22 US disclosed
US-4689336-A Hypoglycemic 5-substituted oxazolidine 2,4-diones PFIZER INC. (US) 1987-08-25 US disclosed
US-4622406-A CHEMICAL INTERMEDIATES, TRIMETHYLSILOXY COMPOUNDS PFIZER INC. (US) 1986-11-11 US disclosed
US-4423233-A ALPHA-HYDROXY CARBOXIMIDATE INTERMEDIATES PFIZER INC. (US) 1983-12-27 US disclosed
US-4407811-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-10-04 US disclosed
US-4399296-A TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES PFIZER INC. (US) 1983-08-16 US disclosed
US-4381308-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-04-26 US disclosed
US-4367234-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1983-01-04 US disclosed
US-4342771-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1982-08-03 US disclosed
US-4332952-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1982-06-01 US disclosed
US-4332905-A STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF RACEMIC 5-SUBSTITUTED 2,4-OXAZOLIDINEDIONES E.N.I. ENTE NOZIONALE IDROCARBURI (IT) 1982-06-01 US disclosed
US-4314023-A AZO-METHINE DYES KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1982-02-02 US disclosed