Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.54 |
| ▸ | JUN | P05412 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNK | O75909 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.51 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558138 | 1.00 | MAPK8 (0.56) | MAPK8MAPK10GSK3AGSK3BADORA1 | |
| SCHEMBL16666131 | 0.86 | NPY5R (0.50) | MAPK8MAPK10ADORA1MAPK9MKNK1 | |
| SCHEMBL558347 | 0.84 | NPY5R (0.52) | MAPK8MAPK10ADORA1MAPK9MKNK1 | |
| SCHEMBL31108105 | 0.82 | CDK2 (0.56) | MAPK8MAPK10MAPK9CDK2CCNK | |
| SCHEMBL31094578 | 0.82 | CDK2 (0.50) | MAPK8MAPK10MAPK9CDK2CCNK | |
| SCHEMBL559142 | 0.81 | MAPK8 (0.55) | MAPK8MAPK10GSK3AGSK3BADORA1 | |
| SCHEMBL28234157 | 0.81 | CCNA2 (0.49) | MAPK10JUNRIPK2CDK2CCNK | |
| SCHEMBL559141 | 0.81 | MAPK8 (0.55) | MAPK8MAPK10GSK3AGSK3BADORA1 | |
| SCHEMBL28282290 | 0.81 | CCNA2 (0.46) | MKNK1MKNK2CDK2CCNKCCNA2 | |
| SCHEMBL25107028 | 0.80 | RIPK2 (0.53) | MAPK8MAPK10GSK3AGSK3BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630529-B2 | GCN2 modulator compounds | Alesta Therapeutics BV (NL) | 2026-05-19 | — | — | US | claimed |
| US-20230143059-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2023-05-11 | — | — | US | claimed |
| US-12630529-B2 | GCN2 modulator compounds | Alesta Therapeutics BV (NL) | 2026-05-19 | — | — | US | disclosed |
| US-20230143059-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2023-05-11 | — | — | US | disclosed |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12630529-B2 | GCN2 modulator compounds | NR3C1, GCN1, EIF2AK4 | MAPK8 1020/4885MAPK10 833/4885GSK3A 1904/4885 |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | MAPK8 20/4885MAPK10 32/4885GSK3A 635/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | MAPK8 20/4885MAPK10 32/4885GSK3A 635/4885 |
| US-20230143059-A1 | GCN2 MODULATOR COMPOUNDS | EIF2AK4, GPR119, GCN1 | MAPK8 1170/4885MAPK10 272/4885GSK3A 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.