Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581996 | 0.87 | AKR1C3 (0.46) | AKR1C3AKR1C2PDE4DPDE4BABCG2 | |
| SCHEMBL5582022 | 0.83 | ABCG2 (0.40) | AKR1C3AKR1C2PDE4DPDE4BABCG2 | |
| SCHEMBL5581720 | 0.81 | MAPT (0.51) | PDE4DPDE4BL3MBTL1MAPTALDH1A1 | |
| SCHEMBL5582203 | 0.79 | HPGDS (0.47) | PDE4DABCG2LMNACYP1A2MEN1 | |
| SCHEMBL5581890 | 0.78 | PDE4A (0.46) | AKR1C3AKR1C2PDE4DPDE4BPOLB | |
| SCHEMBL3037892 | 0.71 | ADORA1 (0.47) | AKR1C3AKR1C2PDE4DPDE4BL3MBTL1 | |
| SCHEMBL5582130 | 0.70 | POLB (0.41) | AKR1C3AKR1C2PDE4DPDE4BABCG2 | |
| SCHEMBL3787713 | 0.69 | AKR1C3 (0.60) | AKR1C3AKR1C2ABCG2POLBL3MBTL1 | |
| SCHEMBL6756916 | 0.69 | PDE4D (0.54) | AKR1C3AKR1C2PDE4DPDE4BPOLB | |
| SCHEMBL3037890 | 0.69 | AKR1C3 (0.49) | AKR1C3AKR1C2PDE4DPDE4BABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | AKR1C3 1137/4885AKR1C2 970/4885PDE4D 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.