Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582253 | 0.87 | KIT (0.49) | HPGDSLRRK2KITSCN9ABRAF | |
| SCHEMBL5581743 | 0.83 | ALDH1A1 (0.40) | PRKCQALPLPDE4D | |
| SCHEMBL5581557 | 0.81 | POLQ (0.35) | HPGDSLRRK2POLQBRAFP4HTM | |
| SCHEMBL5582341 | 0.79 | PDE4D (0.45) | KITBRAFPDE4D | |
| SCHEMBL5582139 | 0.78 | NPC1 (0.54) | PRKCQKIT | |
| SCHEMBL5582243 | 0.78 | IDO1 (0.42) | KIT | |
| SCHEMBL5582334 | 0.77 | ALDH1A1 (0.40) | LRRK2KITSCN9APDE4D | |
| SCHEMBL5582316 | 0.76 | SLC22A12 (0.42) | LRRK2POLQ | |
| SCHEMBL5581786 | 0.76 | ALDH1A1 (0.41) | LRRK2PRKCQKITALPLSCN9A | |
| SCHEMBL5581811 | 0.75 | PDGFRB (0.43) | LRRK2PRKCQSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | HPGDS 4270/4885LRRK2 176/4885PRKCQ 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.