Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SIK1 | P57059 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582220 | 0.90 | LRRK2 (0.39) | LRRK2MERTKAXLTYRO3ALDH1A1 | |
| SCHEMBL5581909 | 0.85 | ALDH1A1 (0.46) | LRRK2SIK1SIK2SIK3ALDH1A1 | |
| SCHEMBL5582243 | 0.83 | IDO1 (0.42) | MERTKAXLTYRO3KMT2ANPC1 | |
| SCHEMBL5581786 | 0.81 | ALDH1A1 (0.41) | LRRK2MERTKALOX15SIK2TYRO3 | |
| SCHEMBL5581811 | 0.81 | PDGFRB (0.43) | LRRK2SIK2SIK3ALDH1A1CLK4 | |
| SCHEMBL5582209 | 0.80 | PTK2 (0.46) | MERTKCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5582334 | 0.80 | ALDH1A1 (0.40) | LRRK2SIK2ALDH1A1CRHR1PDE4D | |
| SCHEMBL5582108 | 0.79 | PAK1 (0.39) | LRRK2MERTKPAK1TSHRCYP1A2 | |
| SCHEMBL5582323 | 0.78 | PDGFRB (0.42) | LRRK2MERTKAXLTYRO3ALDH1A1 | |
| SCHEMBL5581749 | 0.78 | FYN (0.43) | SIK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | LRRK2 176/4885MERTK 4744/4885PAK1 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.