Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14524732 | 1.00 | MAOA (0.46) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL5582279 | 1.00 | MAOA (0.46) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL29038278 | 0.71 | TYR (0.56) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL29038274 | 0.71 | TYR (0.56) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL29038239 | 0.69 | MAOB (0.52) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL29038268 | 0.69 | CYP19A1 (0.71) | MAOAMAOBCYP19A1TNF | |
| SCHEMBL29038235 | 0.69 | MAOB (0.52) | MAOAMAOBIKBKBHSD11B1CYP19A1 | |
| SCHEMBL29038266 | 0.69 | CYP19A1 (0.71) | MAOAMAOBCYP19A1TNF | |
| SCHEMBL29038276 | 0.67 | MAOB (0.78) | MAOAMAOBHSD11B1CYP19A1 | |
| SCHEMBL29038279 | 0.67 | MAOB (0.78) | MAOAMAOBHSD11B1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| EP-1680447-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040212-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | TCF12, JUN, TCF7 | MAOA 3826/4885MAOB 4094/4885IKBKB 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.