Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582411 | 0.89 | LMNA (0.41) | CASP6LMNAHTTMAPK1HSP90AA1 | |
| SCHEMBL18203769 | 0.76 | SCN9A (0.43) | CASP6LMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL2789458 | 0.72 | CYP19A1 (0.47) | CASP6LMNASMN1; SMN2HPGDMEN1 | |
| SCHEMBL24977286 | 0.70 | EPHX2 (0.41) | LMNAHTTMAPK1SMN1; SMN2HPGD | |
| SCHEMBL2415309 | 0.67 | EPHX2 (0.58) | SMN1; SMN2HPGDMEN1KMT2ACYP1A2 | |
| SCHEMBL26259974 | 0.67 | SCN9A (0.43) | CASP6SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL29788605 | 0.65 | MEN1 (0.47) | LMNAMAPK1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL28548601 | 0.65 | MEN1 (0.47) | LMNAMAPK1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL14754342 | 0.63 | CASP6 (0.48) | CASP6SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL4053984 | 0.63 | EPHX2 (0.49) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | disclosed |