Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | MPL | P40238 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ITK | Q08881 | 6/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583293 | 0.89 | ACHE (0.46) | PIM3KIF11MAPTITKGABRP | |
| SCHEMBL5583310 | 0.79 | KIF11 (0.58) | PIM3MPLKIF11MAPTGABRP | |
| SCHEMBL844918 | 0.74 | PIM3 (0.56) | PIM3MPLKIF11ITKRXFP1 | |
| SCHEMBL5583274 | 0.74 | NOS1 (0.51) | PIM3MAPTGABRPGABRDGABRA1 | |
| SCHEMBL5583287 | 0.74 | PIM3 (0.60) | PIM3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14366529 | 0.74 | MAPT (0.45) | MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL20060303 | 0.74 | KDM4E (0.59) | MAPTCDK2KDM4EALDH1A1MEN1 | |
| SCHEMBL12354 | 0.74 | KDM4E (0.59) | MAPTCDK2KDM4EALDH1A1MEN1 | |
| SCHEMBL5582982 | 0.74 | KDM4E (0.54) | PIM3MAPTRXFP1CCNB2CDK1 | |
| SCHEMBL5583145 | 0.73 | MAPT (0.47) | KIF11MAPTGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254877-A1 | Indole Derivative and Use for Treatment of Cancer | TAKADA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-11-01 | — | — | US | claimed |
| US-20070254877-A1 | Indole Derivative and Use for Treatment of Cancer | TAKADA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254877-A1 | Indole Derivative and Use for Treatment of Cancer | IGF1R, KDR, ERBB2 | PIM3 474/4885MPL 1102/4885KIF11 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.