SCHEMBL5583593

SCHEMBL5583593

COc1ccnc(C(=O)Nc2ccc(Oc3ccc(N)cc3)cc2)c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AXL P30530 3/20 0.46
PDGFRA P16234 5/20 0.45
KDR P35968 5/20 0.45
RAB9A P51151 5/20 0.44
LMNA P02545 1/20 0.44
NPC1 O15118 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
TP53 P04637 2/20 0.44
PRKCI P41743 1/20 0.44
PKM P14618 2/20 0.44
ALDH1A1 P00352 1/20 0.44
PNLIP P16233 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
PDGFRB P09619 1/20 0.43
HDAC3 O15379 1/20 0.43
BRAF P15056 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5583655 0.91 RAB9A (0.53) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL5583670 0.89 KDR (0.55) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL2237038 0.89 RAB9A (0.53) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL14284595 0.88 KDR (0.55) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL5583777 0.87 NPC1 (0.60) RAB9ALMNANPC1SMN1; SMN2TP53
SCHEMBL5583850 0.86 KDR (0.50) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL5583638 0.86 AXL (0.44) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL5584055 0.86 ABCC1 (0.53) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL14284589 0.86 RAB9A (0.62) AXLPDGFRAKDRRAB9ALMNA
SCHEMBL5583773 0.85 EPHX2 (0.53) RAB9ANPC1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed