Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL21585545 | 1.00 | TSHR (0.50) | TSHREGLN1TP53EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL28993981 | 0.93 | PHF8 (0.56) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL15653011 | 0.87 | EGLN1 (0.39) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL15653012 | 0.87 | EGLN1 (0.39) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL1144213 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL10941648 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL31420005 | 0.85 | — | — | |
| Acetoacetic Acid SCHEMBL21402364 | 0.85 | — | — | |
| Acetoacetic Acid SCHEMBL1406366 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL28972036 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113853209-B | Novel AAV capsids and compositions containing same | 宾夕法尼亚州大学信托人 | 2024-12-13 | — | — | CN | disclosed |
| CN-118510446-A | Non-invasive analyte sensor with temperature compensation | 知识实验室股份有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-118251171-A | Noise reduction in non-invasive radio frequency analyte sensors | 知识实验室股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117320624-A | Creating an analyte database using analyte data from a non-invasive analyte sensor | 知识实验室股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-117223171-A | Antenna array for non-invasive analyte sensor | 知识实验室股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-116801806-A | Fixed operation time frequency scanning for analyte sensors | 知识实验室股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-112004820-B | Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism | 利兰斯坦福初级大学董事会 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022111696-A1 | MAINTENANCE OF PROGRAMMED CHRONIC LIVER INJURY OF FAH GENE-DEFICIENT ANIMALS AND APPLICATION THEREOF IN PREPARATION OF HETEROLOGOUS LIVER MODELS | 江苏大学 | 2022-06-02 | — | — | WO | disclosed |
| US-20070078088-A1 | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules | MILLENNIUM PHARMACEUTICALS, INC. | 2007-04-05 | — | — | US | disclosed |
| US-20030157082-A1 | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480,20893, 33230,1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules | MILLENNIUM PHARMACEUTICALS, INC. | 2003-08-21 | — | — | US | disclosed |