Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5583845 | 1.00 | TSHR (0.50) | TSHREGLN1TP53EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL28993981 | 0.93 | PHF8 (0.56) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL15653011 | 0.87 | EGLN1 (0.39) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL15653012 | 0.87 | EGLN1 (0.39) | TSHREGLN1TP53EGLN3HCAR2 | |
| Acetoacetic Acid SCHEMBL1144213 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL10941648 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL31420005 | 0.85 | — | — | |
| Acetoacetic Acid SCHEMBL21402364 | 0.85 | — | — | |
| Acetoacetic Acid SCHEMBL1406366 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C | |
| Acetoacetic Acid SCHEMBL28972036 | 0.85 | LDHA (0.57) | TSHREGLN1KDM4EKDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116724119-A | Herbicide resistant plants | 苏州齐禾生科生物科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2019233349-A1 | MUTANT P-HYDROXYPHENYLPYRUVATE DIOXYGENASE, AND CODING NUCLEIC ACID AND USE THEREOF | 青岛清原化合物有限公司 (CN) | 2019-12-12 | — | — | WO | disclosed |