Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1954323 | 0.84 | ALDH1A1 (0.51) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL5784751 | 0.81 | NPC1 (0.53) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL10367560 | 0.81 | ALDH1A1 (0.49) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL470906 | 0.79 | CA12 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30541768 | 0.79 | CA12 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL3825460 | 0.78 | CA12 (0.64) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28059356 | 0.78 | ALDH1A1 (0.55) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL27620749 | 0.78 | NPC1 (0.53) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL826938 | 0.78 | ALDH1A1 (0.55) | NPC1RAB9APOLBALDH1A1CYP3A4 | |
| SCHEMBL27891386 | 0.78 | NPC1 (0.53) | NPC1RAB9APOLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138773-B1 | USE OF QUINOLINE DERIVATIVES FOR THE PROTECTION OF CROP PLANTS | CIBA-GEIGY AG (CH) | 1990-08-29 | — | — | EP | claimed |
| EP-0138773-A2 | Use of quinoline derivatives for the protection of crop plants | CIBA-GEIGY AG (CH) | 1985-04-24 | — | — | EP | claimed |
| CN-100384849-C | Quinoline 3-Aminochroman Derivatives | WYETH CORP (US) | 2008-04-30 | — | — | CN | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| CN-1809574-A | Quinoline 3-amino chroman derivatives | WYETH CORP (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1638976-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | Wyeth (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050004157-A1 | Quinoline 3-amino chroman derivatives | WYETH | 2005-01-06 | — | — | US | disclosed |
| WO-2004099214-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | WYETH (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-0138773-B1 | USE OF QUINOLINE DERIVATIVES FOR THE PROTECTION OF CROP PLANTS | CIBA-GEIGY AG (CH) | 1990-08-29 | — | — | EP | disclosed |
| US-4626591-A | Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4540787-A | Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines | ELI LILLY AND COMPANY (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0138773-A2 | Use of quinoline derivatives for the protection of crop plants | CIBA-GEIGY AG (CH) | 1985-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HTR3C, HTR3A, HTR2C | NPC1 3159/4885RAB9A 1046/4885POLB 2096/4885 |
| US-20050004157-A1 | Quinoline 3-amino chroman derivatives | HTR3C, HTR3A, HTR2C | NPC1 3159/4885RAB9A 1046/4885POLB 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.