Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291764 | 0.82 | ALDH1A1 (0.42) | KDM4EHPGDTSHRHSD17B10KDM5A | |
| SCHEMBL6428004 | 0.81 | CYP2C9 (0.40) | KDM4EHPGDKDM5AADORA2AADORA2B | |
| SCHEMBL5583883 | 0.77 | KDM4E (0.45) | KDM4EHPGDTSHRHSD17B10PDE7A | |
| SCHEMBL13139849 | 0.77 | DPP4 (0.50) | — | |
| SCHEMBL3071647 | 0.77 | DPP4 (0.50) | — | |
| SCHEMBL5583864 | 0.73 | GABRA1 (0.42) | KDM4EHPGDKDM5ACYP2C9CYP2C19 | |
| SCHEMBL5583740 | 0.72 | PIN1 (0.40) | KDM4EHPGDKDM5AADORA2AADORA2B | |
| SCHEMBL5583951 | 0.71 | NPSR1 (0.39) | KDM4EHPGDHSD17B10ADORA2AADORA2B | |
| SCHEMBL8290094 | 0.65 | DPP4 (0.44) | KDM4EHPGDTSHRHSD17B10ADORA2A | |
| SCHEMBL14238617 | 0.65 | POLB (0.43) | KDM4EHPGDKDM5AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505121-A | — | — | 2007-03-08 | — | — | JP | claimed |
| EP-1699777-A1 | DIPEPTIDYL PEPTIDASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2006-09-13 | — | — | EP | claimed |
| WO-2005026148-A1 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050065145-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2005-03-24 | — | — | US | claimed |
| US-7790734-B2 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-07 | — | — | US | disclosed |
| US-7790734-B2 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065145-A1 | Dipeptidyl peptidase inhibitors | DPP4, DPP3, DPP7 | KDM4E 1753/4885HPGD 1891/4885TSHR 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.