Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Biphenyl-4-Amine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL5586139 | 0.82 | MAOA (0.67) | CYP3A4HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL6529683 | 0.82 | HTT (0.49) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Benzidine SCHEMBL308333 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Benzidine SCHEMBL29002343 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Benzidine SCHEMBL28050418 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| SCHEMBL24524183 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Biphenyl-4-Amine SCHEMBL20296849 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Biphenyl-4-Amine SCHEMBL15921057 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| SCHEMBL21392391 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 | |
| Biphenyl-4-Amine SCHEMBL27682012 | 0.79 | CYP3A4 (1.00) | CYP3A4HSD17B10TDP1TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270562-A1 | SILOXANE-MODIFIED HYPERBRANCHED POLYIMIDE | NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY (JP) | 2007-11-22 | — | — | US | claimed |
| US-20070270562-A1 | SILOXANE-MODIFIED HYPERBRANCHED POLYIMIDE | NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY (JP) | 2007-11-22 | — | — | US | disclosed |