Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67251 | 0.80 | CYP19A1 (0.41) | MEN1LMNAKMT2AHTT | |
| SCHEMBL26106019 | 0.77 | IDO1 (0.32) | IDO1TDO2HDAC3HDAC4HDAC1 | |
| SCHEMBL26109029 | 0.77 | IDO1 (0.32) | IDO1TDO2HDAC3HDAC4HDAC1 | |
| SCHEMBL6223969 | 0.77 | IDO1 (0.32) | IDO1TDO2HDAC3HDAC4HDAC1 | |
| SCHEMBL27999842 | 0.77 | HTT (0.37) | MEN1LMNAKMT2ASMN1; SMN2HTT | |
| SCHEMBL13619654 | 0.77 | AOC3 (0.44) | SLC6A3GABBR2GABBR1MEN1LMNA | |
| SCHEMBL21855589 | 0.76 | CYP19A1 (0.45) | MEN1LMNAKMT2ASMN1; SMN2HTT | |
| SCHEMBL6871140 | 0.74 | GABBR2 (0.37) | IDO1TDO2HDAC3HDAC4HDAC1 | |
| SCHEMBL9047470 | 0.74 | ALDH1A1 (0.40) | IDO1TDO2SLC6A3LOXL2MEN1 | |
| SCHEMBL3417295 | 0.74 | AOC3 (0.36) | IDO1TDO2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763523-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006003148-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-12 | — | — | WO | disclosed |