Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5586403 | 1.00 | TSHR (0.41) | TSHRTP53EGLN1EGLN3TDP1 | |
| Malic Acid SCHEMBL9406592 | 0.90 | SMN1; SMN2 (0.56) | TSHRTP53EGLN1EGLN3TDP1 | |
| SCHEMBL30293 | 0.88 | TDP1 (0.48) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| SCHEMBL8558212 | 0.85 | TDP1 (0.46) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| SCHEMBL9406499 | 0.85 | TDP1 (0.46) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| SCHEMBL9406869 | 0.85 | TDP1 (0.46) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| SCHEMBL9053647 | 0.85 | TDP1 (0.46) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| Ammonia Solution, Strong SCHEMBL28156292 | 0.85 | TDP1 (0.52) | TSHRTDP1SMN1; SMN2SLC22A6FOLH1 | |
| SCHEMBL646453 | 0.81 | HCAR2 (0.50) | TSHRTP53EGLN1EGLN3TDP1 | |
| SCHEMBL3716837 | 0.81 | HCAR2 (0.50) | TSHRTP53EGLN1EGLN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3942011-B2 | — | — | 2007-07-11 | — | — | JP | claimed |
| EP-1235820-B1 | ETHER-CAPPED POLY(OXYALKYLATED) ALCOHOL SURFACTANTS | PROCTER & GAMBLE (US) | 2006-08-23 | — | — | EP | claimed |
| US-6844309-B1 | Ether-capped poly(oxyalkylated) alcohol surfactants | THE PROCTER & GAMBLE COMPANY (US) | 2005-01-18 | — | — | US | claimed |
| JP-2003516424-A | — | — | 2003-05-13 | — | — | JP | claimed |
| EP-1235820-A2 | ETHER-CAPPED POLY(OXYALKYLATED) ALCOHOL SURFACTANTS | THE PROCTER & GAMBLE COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001042408-A2 | ETHER-CAPPED POLY(OXYALKYLATED) ALCOHOL SURFACTANTS | THE PROCTER & GAMBLE COMPANY (US) | 2001-06-14 | — | — | WO | claimed |