Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.53 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351119 | 0.80 | PTGS2 (0.69) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL8301422 | 0.79 | ELANE (0.43) | CYP3A4KMT2AKDM4E | |
| SCHEMBL7404085 | 0.79 | ELANE (0.43) | CYP3A4KMT2AKDM4E | |
| SCHEMBL8344019 | 0.77 | PTGS2 (0.63) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL3060996 | 0.76 | ENPP3 (0.41) | ADORA3ALDH1A1 | |
| SCHEMBL3803839 | 0.76 | ENPP3 (0.41) | ADORA3ALDH1A1 | |
| SCHEMBL28370009 | 0.75 | PTGS2 (0.71) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL27539865 | 0.75 | KMT2A (0.44) | LMNACYP3A4SLC6A2ALDH1A1KMT2A | |
| SCHEMBL28053565 | 0.74 | PTGS2 (0.67) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6013897 | 0.73 | PTGS2 (0.76) | PTGS2MT-CO2PTGS1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379513-B1 | PRODRUGS OF COX-2 INHIBITORS | PHARMACIA CORP (US) | 2007-08-22 | — | — | EP | claimed |
| US-20040002522-A1 | Prodrugs of COX-2 inhibitors | PHARMACIA CORPORATION | 2004-01-01 | — | — | US | claimed |
| EP-1379513-B1 | PRODRUGS OF COX-2 INHIBITORS | PHARMACIA CORP (US) | 2007-08-22 | — | — | EP | disclosed |
| US-20050032852-A1 | Prodrugs of cox-2 inhibitors | CARTER JEFFERY S (US) | 2005-02-10 | — | — | US | disclosed |
| US-6809111-B2 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PHARMACIA CORPORATION | 2004-10-26 | — | — | US | disclosed |
| US-20040002522-A1 | Prodrugs of COX-2 inhibitors | PHARMACIA CORPORATION | 2004-01-01 | — | — | US | disclosed |
| US-6613790-B2 | For therapy of cyclooxygenase-2 mediated disease | PHARMACIA CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20030055012-A1 | Prodrugs of COX-2 inhibitors | PHARMACIA CORPORATION | 2003-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055012-A1 | Prodrugs of COX-2 inhibitors | PTGS2, PTGS1, PTGES2 | PTGS2 1/4885MT-CO2 2037/4885PTGS1 2/4885 |
| US-20040002522-A1 | Prodrugs of COX-2 inhibitors | PTGS2, PTGS1, PTGES2 | PTGS2 1/4885MT-CO2 2037/4885PTGS1 2/4885 |
| US-20050032852-A1 | Prodrugs of cox-2 inhibitors | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885MT-CO2 2024/4885PTGS1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.