Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | WNT3 | P56703 | 2/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301422 | 1.00 | ELANE (0.43) | ELANECYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL27539865 | 0.96 | KMT2A (0.44) | ELANECYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL3803839 | 0.86 | ENPP3 (0.41) | CYP2D6CYP1A2SCN4AENPP3ENPP1 | |
| SCHEMBL9538667 | 0.86 | ENPP3 (0.41) | ELANEHTR2CHTR2BSCN4AKMT2A | |
| SCHEMBL3060996 | 0.86 | ENPP3 (0.41) | CYP2D6CYP1A2SCN4AENPP3ENPP1 | |
| SCHEMBL8212865 | 0.83 | DPP4 (0.45) | DPP4TSHRHTR6KDM4E | |
| SCHEMBL7070285 | 0.80 | HTR2C (0.43) | ELANEHTR2CSCN4AKMT2AKDM4E | |
| SCHEMBL7754536 | 0.79 | HTR2C (0.46) | ELANECYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL5717063 | 0.79 | ENPP3 (0.46) | KMT2AENPP3ENPP1ENPP2 | |
| SCHEMBL5586750 | 0.79 | PTGS2 (0.53) | CYP3A4KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105126-A2 | SULFONAMIDES OF N-CONTAINING HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL Holdings, Inc. (US) | 2001-06-13 | — | — | EP | claimed |
| WO-2000009107-A2 | SULFONAMIDES OF N-CONTAINING HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1105126-A2 | SULFONAMIDES OF N-CONTAINING HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL Holdings, Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| EP-0983054-A1 | HAIR GROWTH COMPOSITIONS AND USES | GPI NIL Holdings, Inc. (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-2000009107-A2 | SULFONAMIDES OF N-CONTAINING HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-1998055090-A1 | HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-10 | — | — | WO | disclosed |