SCHEMBL5589136

SCHEMBL5589136

Cc1c(C)c(OC(=O)O)c(O)c(-c2ccccc2)c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.48
PDE4A P27815 5/20 0.48
PDE4C Q08493 5/20 0.48
PDE4D Q08499 5/20 0.48
SENP1 Q9P0U3 2/20 0.40
PREP P48147 2/20 0.40
CELA1 Q9UNI1 1/20 0.40
UCHL1 P09936 1/20 0.37
USP5 P45974 1/20 0.37
USP4 Q13107 1/20 0.37
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
KMT2A Q03164 1/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5588225 0.76 IMPDH2 (0.36) IMPDH2
SCHEMBL28949416 0.76 SENP1 (0.54) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL5589914 0.74 PDE4B (0.39) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL5589126 0.74 SENP1 (0.58) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL17698882 0.73 KMT2A (0.44) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL5588923 0.73 PDE4A (0.48) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL15090870 0.72 HSD17B10 (0.43) SENP1PREPCELA1LMNAKMT2A
SCHEMBL5589600 0.72 PDE4A (0.44) PDE4BPDE4APDE4CPDE4DPREP
SCHEMBL12589341 0.71 PDE4B (0.49) PDE4BPDE4APDE4CPDE4DSENP1
SCHEMBL5588866 0.71 KDM4E (0.38) PDE4BPDE4APDE4CPDE4DLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7247687-B2 Late transition metal catalysts for olefin polymerization and oligomerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-07-24 US disclosed
EP-1521758-B1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION EXXONMOBIL CHEM PATENTS INC (US) 2006-05-24 EP disclosed
US-20060047094-A1 Late transition metal catalysts for olefin polymerization and oligomerization EXXONMOBIL CHEMICAL PATENTS INC. 2006-03-02 US disclosed
EP-1521758-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION Exxonmobil Chemical Patents Inc. (US) 2005-04-13 EP disclosed
WO-2004007509-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2004-01-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060047094-A1 Late transition metal catalysts for olefin polymerization and oligomerization MLX, LOX, LMTK3 PDE4B 4878/4885PDE4A 4875/4885PDE4C 4881/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.