Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785358 | 0.79 | KIF11 (0.47) | KIF11TRPV1ALDH1A1GFER | |
| SCHEMBL22693261 | 0.73 | ESR1 (0.67) | KIF11ESR1ESR2SLC6A2P2RY14 | |
| SCHEMBL3636461 | 0.73 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL9418157 | 0.69 | ESR1 (0.47) | ESR1ESR2NPC1ALDH1A1POLB | |
| SCHEMBL678508 | 0.69 | KIF11 (1.00) | KIF11ESR1ESR2DGAT1KCNH2 | |
| SCHEMBL12675678 | 0.69 | KIF11 (1.00) | KIF11ESR1ESR2DGAT1KCNH2 | |
| SCHEMBL1979146 | 0.68 | KIF11 (0.59) | KIF11ESR1ESR2DGAT1KCNH2 | |
| SCHEMBL28269023 | 0.68 | KIF11 (0.52) | KIF11ESR1ESR2DGAT1KCNH2 | |
| SCHEMBL6067861 | 0.67 | KIF11 (0.63) | KIF11ESR1ESR2PTGS1SNCA | |
| SCHEMBL10594294 | 0.67 | ESR2 (0.52) | ESR1ESR2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076104-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2007-07-05 | — | — | WO | disclosed |