Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592071 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNANPC1RAB9ATP53 | |
| SCHEMBL5591894 | 0.89 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNANPC1RAB9ATP53 | |
| SCHEMBL5591878 | 0.84 | SIGMAR1 (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1DRD4 | |
| SCHEMBL5591921 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNANPC1RAB9ATP53 | |
| SCHEMBL5591932 | 0.78 | MAPT (0.56) | NPC1RAB9ADRD4MEN1KMT2A | |
| SCHEMBL5591913 | 0.77 | LMNA (0.56) | SMN1; SMN2LMNANPC1RAB9ATP53 | |
| SCHEMBL13791587 | 0.76 | SIGMAR1 (0.72) | SMN1; SMN2LMNANPC1RAB9ATP53 | |
| SCHEMBL27253620 | 0.74 | SIGMAR1 (0.80) | SMN1; SMN2LMNAKDM4EALDH1A1DRD4 | |
| SCHEMBL5591867 | 0.73 | KDM4E (0.53) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5591939 | 0.73 | SIGMAR1 (0.64) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007104696-A1 | ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-09-20 | — | — | WO | disclosed |