Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598696 | 0.80 | CHRM4 (0.36) | CHRM4GLP1RDOT1LAURKACSNK2A1 | |
| SCHEMBL30613713 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL26136059 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL30800065 | 0.66 | NR4A2 (0.44) | AURKAALDH1A1CHKACASP6NR4A2 | |
| SCHEMBL1556897 | 0.66 | NR4A2 (0.44) | AURKAALDH1A1CHKACASP6NR4A2 | |
| SCHEMBL6468054 | 0.66 | ALDH1A1 (0.36) | KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL31298596 | 0.64 | CHRM4 (0.34) | CHRM4AURKAKDM4EALDH1A1POLB | |
| SCHEMBL18260543 | 0.64 | PDGFRB (0.41) | DOT1LKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31335242 | 0.64 | SMN1; SMN2 (0.34) | HIPK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL26135608 | 0.64 | SMN1; SMN2 (0.34) | HIPK2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |