Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 1/20 | 0.31 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CHKA | P35790 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | STK4 | Q13043 | 1/20 | 0.30 |
| ▸ | STK3 | Q13188 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591985 | 0.80 | CHRM4 (0.36) | CHRM4AURKACSNK2A1HIPK2DOT1L | |
| SCHEMBL7007591 | 0.73 | LRRK2 (0.35) | AURKAHIPK2LRRK2KDM4EALDH1A1 | |
| SCHEMBL31298596 | 0.72 | CHRM4 (0.34) | CHRM4AURKAHTTKDM4EALDH1A1 | |
| SCHEMBL29404834 | 0.69 | PARP1 (0.50) | AURKALRRK2KDM4EALDH1A1AURKB | |
| SCHEMBL6465602 | 0.69 | PARP1 (0.50) | AURKALRRK2KDM4EALDH1A1AURKB | |
| SCHEMBL30629503 | 0.68 | HCAR1 (0.33) | AURKALRRK2KDM4EALDH1A1AURKB | |
| SCHEMBL14180517 | 0.67 | DOT1L (0.41) | DOT1LHTTKDM4EALDH1A1POLB | |
| SCHEMBL6004107 | 0.67 | NR4A2 (0.34) | AURKALRRK2KDM4EALDH1A1AURKB | |
| SCHEMBL8603889 | 0.67 | PARP1 (0.44) | AURKAKDM4EALDH1A1AURKB | |
| SCHEMBL27764233 | 0.67 | MAPT (0.52) | HTTKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |