Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | GLRA1 | P23415 | 14/20 | 0.56 |
| ▸ | GLRB | P48167 | 14/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brucine SCHEMBL1748435 | 0.89 | TAS2R10 (0.67) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL1748414 | 0.89 | TAS2R10 (0.67) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL7546669 | 0.83 | TAS2R10 (0.94) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL14029321 | 0.83 | TAS2R10 (1.00) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL10307298 | 0.83 | TAS2R10 (1.00) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL19476145 | 0.83 | TAS2R10 (1.00) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL1648976 | 0.83 | TAS2R10 (1.00) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL12293782 | 0.83 | TAS2R10 (1.00) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL7753865 | 0.83 | TAS2R10 (0.84) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB | |
| Brucine SCHEMBL7253414 | 0.82 | TAS2R10 (0.98) | TAS2R10CHRM1SMN1; SMN2GLRA1GLRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009706-A2 | SUBSTITUTED PYRAZOLINE COMPOUNDS, HAVING PREDETERMINED STEREOCHEMISTRY, FOR REDUCING TRIGLYCERIDES IN BLOOD | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-01-25 | — | — | WO | disclosed |