Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.70 |
| ▸ | CTSK | P43235 | 4/20 | 0.70 |
| ▸ | CTSL | P07711 | 3/20 | 0.70 |
| ▸ | CTSB | P07858 | 2/20 | 0.70 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 3/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | MC1R | Q01726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592915 | 0.97 | CTSS (0.72) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5592755 | 0.96 | CTSS (0.73) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL8242433 | 0.95 | CTSL (0.71) | CTSSCTSKCTSLCTSBTBK1 | |
| Trifluoroacetic Acid SCHEMBL5592680 | 0.95 | CTSS (0.64) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5592866 | 0.94 | CTSL (0.72) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5592751 | 0.92 | CTSL (0.59) | CTSSCTSKCTSLCTSBPTGER1 | |
| SCHEMBL5592558 | 0.91 | CTSL (0.73) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5592944 | 0.91 | CTSL (0.73) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL8243023 | 0.91 | CTSS (0.83) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL8243570 | 0.90 | CTSL (0.67) | CTSSCTSKCTSLCTSBTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025776-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |