Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6914764 | 0.76 | RAPGEF4 (0.32) | RAPGEF4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2046871 | 0.67 | RAPGEF4 (0.32) | RAPGEF4 | |
| SCHEMBL22228249 | 0.65 | RAPGEF4 (0.31) | RAPGEF4 | |
| SCHEMBL22361203 | 0.60 | RAPGEF4 (0.44) | RAPGEF4NPSR1MAPTMEN1KMT2A | |
| SCHEMBL598081 | 0.60 | MEN1 (0.47) | RAPGEF4NPSR1MAPTMEN1KMT2A | |
| SCHEMBL31261723 | 0.60 | MEN1 (0.47) | RAPGEF4NPSR1MAPTMEN1KMT2A | |
| SCHEMBL1551822 | 0.58 | RAPGEF4 (0.59) | RAPGEF4ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL317299 | 0.58 | RAPGEF4 (0.50) | RAPGEF4ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL28951 | 0.58 | RAPGEF4 (0.59) | RAPGEF4ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL21509795 | 0.57 | HTR2A (0.37) | RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007029021-A1 | 1,5-SUBSTITUTED TETRAZOLES AS THERAPEUTIC COMPOUNDS | THE UNIVERSITY OF EDINBURGH (GB) | 2007-03-15 | — | — | WO | disclosed |