Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593303 | 0.83 | RAF1 (0.59) | MAPK14RAF1BRAF | |
| SCHEMBL5603999 | 0.81 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5592959 | 0.79 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4551494 | 0.79 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4417398 | 0.77 | TEK (0.54) | RAF1BRAF | |
| SCHEMBL4410223 | 0.75 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4411272 | 0.75 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6079594 | 0.75 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4727303 | 0.74 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5593445 | 0.74 | RAF1 (0.58) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |