Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 10/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417490 | 0.86 | TEK (0.46) | TEKBRAFRAF1 | |
| SCHEMBL5593368 | 0.81 | GAA (0.43) | BRAFMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5593016 | 0.79 | TEK (0.53) | TEKBRAFMEN1KMT2ANAMPT | |
| SCHEMBL4417402 | 0.78 | TEK (0.54) | TEKBRAFMEN1KMT2ADDR1 | |
| SCHEMBL5592958 | 0.77 | MAPK14 (0.54) | BRAFRAF1 | |
| SCHEMBL5593400 | 0.70 | RAF1 (0.46) | TEKBRAFHIF1AEPAS1NPC1 | |
| SCHEMBL15123210 | 0.70 | TEK (1.00) | TEK | |
| SCHEMBL4417829 | 0.69 | TEK (0.45) | TEKBRAFRAF1 | |
| SCHEMBL4419811 | 0.69 | TEK (0.46) | TEKBRAFRAF1 | |
| SCHEMBL4565827 | 0.69 | TEK (0.46) | TEKBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |