Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478873 | 0.80 | TDP1 (0.44) | TDP1MAPTIMPDH2POLBHSD17B10 | |
| SCHEMBL26032832 | 0.78 | TDP1 (0.62) | TDP1MAPTNR1H4TNFRSF1AAKR1C3 | |
| SCHEMBL13763259 | 0.76 | TDP1 (0.44) | TDP1MAPTNR1H4TNFRSF1AAKR1C3 | |
| SCHEMBL4727300 | 0.76 | TDP1 (0.44) | TDP1MAPTNR1H4TNFRSF1AAKR1C3 | |
| SCHEMBL25762024 | 0.76 | MAPT (0.40) | MAPTIMPDH2ALDH1A1SQOR | |
| SCHEMBL4642918 | 0.74 | ALOX15 (0.42) | GRIA2GRIA4HSD17B10ALDH1A1 | |
| SCHEMBL28363838 | 0.74 | CYP1A2 (0.52) | MAPTALDH1A1 | |
| SCHEMBL7796386 | 0.72 | NR1H4 (0.56) | TDP1MAPTNR1H4TNFRSF1AHSD17B10 | |
| SCHEMBL1505827 | 0.68 | TDP1 (0.61) | TDP1MAPTAKR1C3AKR1C2POLB | |
| SCHEMBL10222517 | 0.67 | AKR1C3 (0.56) | AKR1C3AKR1C2POLBHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |