SCHEMBL4642918

SCHEMBL4642918

CC(C)(C)c1cccc(C(=O)O)c1C#N

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.42
CA2 P00918 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
NOTUM Q6P988 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GRIA4 P48058 5/20 0.38
GRIA2 P42262 4/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RBP4 P02753 1/20 0.37
HTT P42858 1/20 0.37
TAS2R14 Q9NYV8 1/20 0.37
XDH P47989 1/20 0.36
SLC22A12 Q96S37 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL400732 0.83 TAS2R14 (0.47) ALOX15MRGPRX4ALDH1A1KDM4EHPGD
SCHEMBL16953431 0.82 CA2 (0.42) CA2ALDH1A1KDM4EHSD17B10
SCHEMBL21451350 0.79 CA2 (0.48) CA2ALDH1A1KDM4EHPGDSLC22A12
Water SCHEMBL2542359 0.77 ALDH1A1 (0.54) ALOX15CA2ALDH1A1KDM4EHPGD
Ethane SCHEMBL2154464 0.77 CA2 (0.46) CA2ALDH1A1KDM4EHPGDSLC22A12
SCHEMBL16951332 0.77 CA2 (0.37) CA2ALDH1A1HSD17B10
SCHEMBL1352723 0.77 KDM4E (0.55) ALOX15MRGPRX4NOTUMALDH1A1KDM4E
Water SCHEMBL28274879 0.77 ALOX15 (0.46) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL16950994 0.76 CA2 (0.36) CA2ALDH1A1
SCHEMBL39249 0.75 ALDH1A1 (0.56) ALOX15CA2ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116535285-A Photocatalytic benzyl position C (sp 3 ) Method for functionalization of Cl bonds and use thereof 中国科学院理化技术研究所 2023-08-04 CN disclosed
EP-1957460-A1 BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-08-20 EP disclosed
WO-2008021388-A1 HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS KEMIA, INC. (US) 2008-02-21 WO disclosed
WO-2007075896-A2 HETEROCYCLIC CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-07-05 WO disclosed
WO-2007067444-A1 BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-06-14 WO disclosed
WO-2007056016-A2 BISAMIDE CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-18 WO disclosed