Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13133556 | 0.91 | MAPT (0.58) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL17269501 | 0.84 | MAPT (0.41) | MAPTLMNATP53THRBKDM4E | |
| SCHEMBL7525473 | 0.82 | MAPT (0.51) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL5593150 | 0.81 | MEN1 (0.66) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL5016203 | 0.81 | GSK3B (0.42) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL5593010 | 0.81 | KDM4E (0.55) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL5593112 | 0.80 | KDM4E (0.52) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL7526568 | 0.80 | ALDH1A1 (0.56) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL16376438 | 0.79 | KMT2A (0.57) | MAPTLMNATP53KMT2AMEN1 | |
| SCHEMBL5593111 | 0.79 | MAPT (0.57) | MAPTLMNATP53THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007074238-A2 | NOVEL N-ALK-(E)-YLIDENE-N'-PYRIMIDIN-2-YL HYDRAZINE DERIVATIVES AND USE THEREOF AS CYTOPROTECTIVE DRUGS | TROPHOS (FR) | 2007-07-05 | — | — | WO | disclosed |