Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650880 | 0.84 | FPR2 (0.43) | F11KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4128919 | 0.84 | FPR2 (0.43) | F11KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4142875 | 0.80 | F11 (0.43) | F11KMT2AMEN1ROCK2ROCK1 | |
| SCHEMBL8241498 | 0.78 | FPR2 (0.44) | KMT2AMEN1LMNAMAPTROCK2 | |
| SCHEMBL4706516 | 0.66 | F11 (0.49) | F11TACR3 | |
| SCHEMBL4142872 | 0.64 | PTPRB (0.48) | F11KMT2AMEN1LMNAMAPT | |
| SCHEMBL2092941 | 0.63 | SMN1; SMN2 (0.68) | KMT2AMEN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5033885 | 0.61 | ABL1 (0.58) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7251623 | 0.60 | SMN1; SMN2 (0.72) | LMNAMAPTSMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL4707261 | 0.60 | F11 (0.49) | F11KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070816-A2 | THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007070816-A2 | THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |