Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595077 | 0.85 | CXCR2 (0.85) | CXCR2CXCR1MEN1ALDH1A1MAPT | |
| SCHEMBL27498642 | 0.80 | CXCR2 (0.44) | CXCR2CXCR1MEN1ALDH1A1KMT2A | |
| SCHEMBL7489930 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1MEN1ALDH1A1MAPT | |
| SCHEMBL7489083 | 0.77 | CXCR2 (0.69) | CXCR2CXCR1MEN1ALDH1A1MAPT | |
| SCHEMBL5594865 | 0.72 | CXCR2 (0.71) | CXCR2CXCR1MEN1ALDH1A1KMT2A | |
| SCHEMBL3709514 | 0.72 | CXCR2 (0.71) | CXCR2CXCR1MEN1ALDH1A1KMT2A | |
| SCHEMBL27575359 | 0.70 | KEAP1 (0.39) | ALDH1A1MAPTCA1CA2 | |
| SCHEMBL7515127 | 0.69 | CXCR2 (0.66) | CXCR2CXCR1MEN1ALDH1A1MAPT | |
| SCHEMBL10957088 | 0.69 | TDP1 (0.37) | MEN1ALDH1A1MAPTKMT2ACA12 | |
| SCHEMBL8982765 | 0.69 | KDM4E (0.35) | MEN1ALDH1A1MAPTKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |